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Project: Michigan Lupus Epidemiology and Surveillance Program Longitudinal Cohort (MiLES)

Initiated in 2013, MiLES is a newly established cohort study which creates and maintains the MiLES Longitudinal Cohort & Biobank, including lupus cases from the southeast Michigan surveillance registry as well as population-based controls.

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Project: Michigan Bone Health & Metabolism Study (MBHMS Bone Strength)

The 32-year MBHMS follows the daughters of participants in the historic Tecumseh Community Health Study to evaluate the impact of aging-related processes including menopause and the secular increase in obesity on the development and progression of musculoskeletal disease and declines in physical functioning. This study addresses a significant gap in scientific knowledge that impedes our ability to optimize fracture prevention strategies. If our hypotheses prove correct, baseline external bone size may be used as an additional parameter to identify women most likely to lose bone strength rapidly during the MT and who might benefit from early intervention.

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Project: SWAN Genomic Analyses

SWAN Genomic Analyses performed dense genome-wide genotyping and imputation of genetic variants throughout the genome to the Haplotype Reference Consortium (HRC) reference panel in 1538 SWAN participants. This project enables SWAN to participate in genetic consortia focused on reproductive aging as well as risk factors for health and disease in women with data uploaded to dbGaP. We are also conducting gene-based analyses to assess the association of menopausal traits, including vasomotor symptoms, with genetic loci previously identified to be associated with age at menarche and menopause. (AG 017719)

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