Jillian Baker is the 2025-2026 recipient of the A. Regula Herzog Young Investigators Fund, an award designed to support research and training for junior researchers on women and aging. The Herzog Fund is part of the ISR Next Generation Awards from the Institute for Social Research. Jillian is excited to further her research on how intimate partner violence influences aging trajectories for women.
“Menstruation remains a subject cloaked in silence and associated with taboos, even within the realm of scientific inquiry. Lack of dialogue about menstruation, particularly about the changes in bleeding patterns as women approach menopause, leads to women’s lack of knowledge about what is normal.”
Congratulations to Center Doctoral Student Jiaxin Wu, MPH, on her first publication as a lead author in Seminars in Reproductive Medicine.
“Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian aging is characterized by fluctuations in reproductive hormones and determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process is essential for addressing health disparities, improving quality of life, and informing relevant public health strategies. ”
“We are finding exploitative conditions that are unique for women farmworkers around issues of sexual harassment, exposures during pregnancy, challenges with obtaining and having access to proper hygiene and sanitation, particularly during menstruation, and also really important aspects of work-life balance and child care issues that women farmworkers in particular face-” — Alexis J. Handal, PhD, MPH (Co-Study Lead, Michigan Farmworker Project).
“Our data suggests that women with higher blood concentrations of PFOA and PFOS reached menopause earlier … than those with low exposure. This is equivalent to the effect of cigarette smoke, a known reproductive toxicant, where we compared current smokers and nonsmokers.”
“We found that Black and Hispanic women had a higher risk of having surgical menopause... and we found that hypertension occurred about five years earlier, and metabolic outcomes such as diabetes and insulin resistance about 11 years earlier for Black and Hispanic women versus white women.’”
The 35-year MBHMS follows the daughters of participants in the historic Tecumseh Community Health Study to evaluate the impact of aging-related processes including menopause and the secular increase in obesity on the development and progression of musculoskeletal disease and declines in physical functioning. This study addresses a significant gap in scientific knowledge that impedes our ability to optimize fracture prevention strategies. If our hypotheses prove correct, baseline external bone size may be used as an additional parameter to identify women most likely to lose bone strength rapidly during the MT and who might benefit from early intervention.
SWAN Genomic Analyses performed dense genome-wide genotyping and imputation of genetic variants throughout the genome to the Haplotype Reference Consortium (HRC) reference panel in 1538 SWAN participants. This project enables SWAN to participate in genetic consortia focused on reproductive aging as well as risk factors for health and disease in women with data uploaded to dbGaP. We are also conducting gene-based analyses to assess the association of menopausal traits, including vasomotor symptoms, with genetic loci previously identified to be associated with age at menarche and menopause. (AG 017719)
The SWAN Multi-Pollutant Study (MPS) was initiated in 2016 to examine health effects of multiple environmental chemical exposures, including perfluoroalkyl and polyfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs), organochlorine pesticides, polybrominated diphenyl ethers (PBDEs), metals, phenols, phthalates, and organophosphate pesticide among midlife women. Funded through two R01 grants by the National Institute of Environmental Health and Sciences (NIEHS), the SWAN MPS specifically investigates 1) obesity, type-2 diabetes and related metabolic endpoints; and 2) reproductive health including sex steroid hormones, age at menopause and ovarian aging).