Center for Midlife Science: Improving Health, Enhancing Function

SWAN Genomic Analyses

The Study of Women’s Health Across the Nation (SWAN) is a multi-site, multi-ethnic, cohort study of 3,302 African-American, Chinese, Hispanic, Japanese, and White women. This 29-year cohort study of midlife women has made major contributions to scientific understanding of reproductive aging and women’s subsequent risk of chronic disease. SWAN Genomic Analyses performed dense genome-wide genotyping and imputation of genetic variants throughout the genome to the Haplotype Reference Consortium (HRC) reference panel in 1538 SWAN participants. This project enables SWAN to participate in genetic consortia focused on reproductive aging as well as risk factors for health and disease in women with data uploaded to dbGaP. We are also conducting gene-based analyses to assess the association of menopausal traits, including vasomotor symptoms, with genetic loci previously identified to be associated with age at menarche and menopause. (AG 017719)

Key Personnel

  • Siobán D. Harlow, PhD, Principal Investigator
  • Sharon L.R. Kardia, PhD, Co-Investigator
  • Daniel S. McConnell, PhD, Co-Investigator
  • Jennifer Smith, PhD, Co-Investigator
  • Lawrence Bielak, PhD, Co-Investigator
  • Patricia Peyser, PhD, Co-Investigator
  • Edward Ruiz-Narvaez, PhD, Co-Investigator
  • Wei Zhao, Assistant Research Scientist
  • Miao Yu, MS, Statistical Analyst

CLASS Laboratory Site